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US10023562, Example 6 PubChem CID 75204286
CC(C)Nc1cc(Nc2ccc(C#N)cn2)ncc1C(=O)NC1CCC(C(=O)NC2CC2)CC1 -
6-((5-cyano-3-fluoro-2-pyridinyl)amino)-N-((2R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(isopropylamino)nicotinamide PubChem CID 90134506
CC(C)Nc1cc(Nc2ncc(C#N)cc2F)ncc1C(=O)NC[C@@H](F)C(C)(C)O -
6-((5-Cyano-6-((3 S)-3-hydroxy-1-pyrrolidinyl)-2-pyridinyl)amino)-N-((2R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(isopropylamino)nicotinamide PubChem CID 90154856
CC(C)Nc1cc(Nc2ccc(C#N)c(N3CC[C@@H](O)C3)n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O -
6-[(5-cyanopyrimidin-2-yl)amino]-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide CAS 1609544-30-0 PubChem CID 90134560
CC(C)Nc1cc(Nc2ncc(C#N)cn2)ncc1C(=O)NC[C@@H](F)C(C)(C)O -
6-((5-Cyano-2-pyridinyl)amino)-N-((2R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(isopropylamino)nicotinamide PubChem CID 75204171
CC(C)Nc1cc(Nc2ccc(C#N)cn2)ncc1C(=O)NC[C@@H](F)C(C)(C)O -
6-[(3-chloro-5-cyanopyridin-2-yl)amino]-N-[(2S)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide CAS 1609545-64-3 PubChem CID 90154924
CC(C)Nc1cc(Nc2ncc(C#N)cc2Cl)ncc1C(=O)NC[C@H](F)C(C)(C)O -
(R)-6-((5-cyano-3-fluoropyridin-2-yl)amino)-4-(isopropylamino)-N-(3-(3-isopropylureido)butyl)nicotinamide PubChem CID 73774625
CC(C)NC(=O)N[C@H](C)CCNC(=O)c1cnc(Nc2ncc(C#N)cc2F)cc1NC(C)C -
(R)-6-((5-cyano-3-fluoropyridin-2-yl)amino)-N-(2-fluoro-3-methoxypropyl)-4-(isopropylamino)nicotinamide PubChem CID 75202654
COC[C@H](F)CNC(=O)c1cnc(Nc2ncc(C#N)cc2F)cc1NC(C)C -
6-((3-chloro-5-cyano-2-pyridinyl)amino)-N-((2R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(tetrahydro-2H-pyran-4-ylamino)nicotinamide PubChem CID 75204287
CC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2ncc(C#N)cc2Cl)cc1NC1CCOCC1 -
N-(trans-4-acetamidocyclohexyl)-6-((5-cyano-3-fluoro-2-pyridinyl)amino)-4-(isopropylamino)nicotinamide PubChem CID 75204403
CC(=O)NC1CCC(NC(=O)c2cnc(Nc3ncc(C#N)cc3F)cc2NC(C)C)CC1 -
4-(Cyclopropylamino)-N-((2R)-2-fluoro-3-hydroxy-3-methylbutyl)-6-(4-pyrimidinylamino)nicotinamide PubChem CID 75204404
CC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2ccncn2)cc1NC1CC1 -
N-((2R)-2-Fluoro-3-hydroxy-3-methylbutyl)-4-(isopropylamino)-6-(4-pyrimidinylamino)nicotinamide PubChem CID 75204405
CC(C)Nc1cc(Nc2ccncn2)ncc1C(=O)NC[C@@H](F)C(C)(C)O -
4-(Cyclopropylamino)-N-((2R)-2-fluoro-3-hydroxy-3-methylbutyl)-6-((4-(3-pyridinyl)-1,3-thiazol-2-yl)amino)nicotinamide PubChem CID 75204406
CC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2csc(-c3cccnc3)n2)cc1NC1CC1 -
6-((2-(Cyclopropylamino)-4-pyrimidinyl)amino)-N-((2R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(isopropylamino)nicotinamide PubChem CID 90134461
CC(C)Nc1cc(Nc2ccnc(NC3CC3)n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O -
6-((3-chloro-5-cyanopyridin-2-yl)amino)-4-(cyclopropylamino)-N-(2,2-difluoro-3-hydroxy-3-methylbutyl)nicotinamide PubChem CID 90134540
CC(C)(O)C(F)(F)CNC(=O)c1cnc(Nc2ncc(C#N)cc2Cl)cc1NC1CC1 -
6-((3-chloro-5-cyanopyridin-2-yl)amino)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(((S)-1-fluoropropan-2-yl)amino)nicotinamide PubChem CID 90134589
C[C@@H](CF)Nc1cc(Nc2ncc(C#N)cc2Cl)ncc1C(=O)NC[C@@H](F)C(C)(C)O -
N-(1-acetyl-4-piperidinyl)-6-((5-cyano-2-pyridinyl)amino)-4-(isopropylamino)nicotinamide PubChem CID 90135925
CC(=O)N1CCC(NC(=O)c2cnc(Nc3ccc(C#N)cn3)cc2NC(C)C)CC1 -
6-((5-Cyano-2-pyridinyl)amino)-4-(((1S,2S)-2,3-dihydroxy-1-phenylpropyl)amino)-N-methylnicotinamide PubChem CID 90154628
CNC(=O)c1cnc(Nc2ccc(C#N)cn2)cc1N[C@@H](c1ccccc1)[C@H](O)CO -
N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-6-[(5-fluoropyrimidin-4-yl)amino]-4-[(propan-2-yl)amino]pyridine-3-carboxamide PubChem CID 90154871
CC(C)Nc1cc(Nc2ncncc2F)ncc1C(=O)NC[C@@H](F)C(C)(C)O