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Step 1: Preparation of (Z)-2-cyano-3-(dimethylamino)acryloyl chloride and 2-cyanoacetyl chloride PubChem CID 176799640
CN(C)/C=C(/C#N)C(=O)N1CCC(Nc2cc(C(=O)N3CC[C@H](N4CCc5ccccc5C4)[C@@H](O)C3)ncn2)CC1