Example 3-3 - Compound Search

N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)-1-(1- (difluoromethyl)cyclopropyl)-4-(((1R,5S,8r)- PubChem CID 169490319

C[C@H](NC(=O)c1cn(C2(C(F)F)CC2)c(=O)cc1NC1[C@@H]2CC[C@H]1CN(C)C2)c1cccc(C(F)F)c1F

Example 631A methyl (1r,2'S,4S)-4-(3-chloroanilino)-2'-{(2R)-3-[(3-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridin PubChem CID 171918466

COC(=O)C1(Nc2cccc(Cl)c2)CCC2(CC1)c1ccccc1C[C@@H]2C[C@@H](C)COc1ccnc2c(Cl)cn(C)c12

US10227334, Example (S)-3-(3-Hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1- yl)propoxy PubChem CID 54766177

CC1=C(c2cccc(O)c2)[C@H](c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21

US10227334, Example 2-(4-((S)-2-((R)-3-fluoropyrrolidin-1-yl)propoxy)phenyl)-3-(3-hydroxyphenyl)-4- methyl PubChem CID 54767766

CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@H](C)N3CC[C@@H](F)C3)cc2)Oc2ccc(O)cc21

Example 384 Preparation of 1- (3-(7-ethoxy-6- methoxy- quinazolin- 4-yloxy)phenyl)- 3-(1-phenyl-3- (trifluoromethyl PubChem CID 58267731

CCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(F)(F)F)nn4-c4ccccc4)c3)c2cc1OC

Example 388 Preparation of 1- (5- (1,3-difluoro-2- methylpropan-2- yl) isoxazol-3-yl)-3- (3- (7-ethoxy PubChem CID 58267747

CCOc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(C(C)(CF)CF)on4)c3)c2cc1OC

US9670208, Example 132 4-(3-(1-((5-fluoro-2-methoxypyridin-3-yl)methyl)piperidin-3-yl)-[1,2,4]triazolo PubChem CID 118216803

COc1ncc(F)cc1CN1CCCC(c2nnc3cc(-c4ccnc(NC5CCOCC5)n4)ccn23)C1

N-(4-(5-(6-(3-cyanopyrrolo[1,2-b]pyridazin-7-yl)-4-(oxetan-3-ylamino)pyridin-3-yl)-1,3,4-thiadiazol-2 PubChem CID 146382440

CC(=O)NC1CCC(F)(c2nnc(-c3cnc(-c4ccc5cc(C#N)cnn45)cc3NC3COC3)s2)CC1

7-(4-(isopropylamino)-5-(5-((1r,3r)-3-(oxetan-3-ylamino)cyclobutyl)-1,3,4-thiadiazol-2-yl)pyridin-2-yl PubChem CID 146393370

CC(C)Nc1cc(-c2ccc3cc(C#N)cnn23)ncc1-c1nnc(C2CC(NC3COC3)C2)s1

N-((1s,3s)-3-(5-(6-(3-cyanopyrrolo[1,2-b]pyridazin-7-yl)-4-(isopropylamino)pyridin-3-yl)-1,3,4-thiadiazol PubChem CID 146393456

CC(C)Nc1cc(-c2ccc3cc(C#N)cnn23)ncc1-c1nnc(C2CC(NC(=O)OC(C)(C)C)C2)s1

N-((1R,5S,8S)-3-(5-(6-(2-(((1R,2S)-2-aminocyclohexyl)amino)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-4-(((R) PubChem CID 146393498

CC(=O)NC1[C@@H]2CC[C@H]1CN(c1nnc(-c3cnc(-c4ccc5cnc(N[C@@H]6CCCC[C@@H]6N)nn45)cc3N[C@H](C)C#N)s1)C2

First-eluting enantiomer from separation of Example 9 (see footnote 5 in Table 1); 2-{5-[(3-ethoxypyridin PubChem CID 156207597

CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)NC3CCC(C(F)(F)F)NC3)cn2)c1

Example 78: 3-[2-(2-[2-[(4-[[(1S,2S)-4,6-Dichloro-2-[(3R)-3-[methyl(propan-2-yl)amino]piperidin-1-yl] PubChem CID 156403359

CC(C)N(C)[C@@H]1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c3ccc(O[C@H]4c5cc(Cl)cc(Cl)c5C[C@@H]4N4CCC[C@@H](N(C)C(C)C)C4)cc3)cc2)C1

2-(2-chloro-6-fluoro-phenyl)-1- [(1S,3R)-6-fluoro-3-(hydroxymethyl)- 5-(3-hydroxy-3-methyl-butyl)-1- PubChem CID 163241889

C[C@H]1c2ccc(F)c(CCC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1Cl

Example 450A methyl (1r,4r)-4-(3-chloroanilino)-2'-{3-[(pyrimidin-5-yl)oxy]propyl}-2',3'-dihydrospiro PubChem CID 164581927

O=C(O)C1(Nc2cccc(Cl)c2)CCC2(CC1)c1ccccc1CC2CCCOc1cncnc1

Example 778A methyl (1r,2'S,4S)-5'-chloro-4-(3-chloroanilino)-2'-[(2R)-3-hydroxy-2-methylpropyl]-2',3 PubChem CID 164581929

C[C@@H](COc1ccnc2c1[C@H](C)CCC2)C[C@H]1Cc2cc(Cl)ccc2C12CCC(Nc1cccc(Cl)c1)(C(=O)O)CC2

Example 42A (1s,4S)-4-(3-chloro-4-fluoroanilino)-5'-fluoro-2'-[(2R)-3-hydroxy-2-methylpropyl]-2',3'-dihydrospiro PubChem CID 164581990

C[C@@H](COc1ccnc2c1[C@H](C)CCC2)CN1Cc2cc(F)ccc2C12CCC(Nc1ccc(F)c(Cl)c1)(C(=O)O)CC2

Example 475A methyl (1r,4r)-4-(3-chloroanilino)-2'-{3-[(7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin PubChem CID 164582049

COC(=O)C1(Nc2cccc(Cl)c2)CCC2(CC1)c1ccccc1CC2CCCOc1ccnc2c1CCC2O

Example 480A methyl (1r,4r)-4-(3-chloroanilino)-2'-{3-[(1-methyl-2-oxo-2,3-dihydro-1H-indol-5-yl)oxy] PubChem CID 164582122

CN1C(=O)Cc2cc(OCCCC3Cc4ccccc4C34CCC(Nc3cccc(Cl)c3)(C(=O)O)CC4)ccc21

Example 451A methyl (1r,4r)-4-(3-chloroanilino)-2'-{3-[(pyrimidin-5-yl)oxy]propyl}-2',3'-dihydrospiro PubChem CID 164582133

COC(=O)C1(Nc2cccc(Cl)c2)CCC2(CC1)c1ccccc1CC2CCCOc1ccnc2c1CCCC2

Compound Database