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4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-6-((3R,4R)-3-fluorotetrahydro-2H-pyran-4-yl PubChem CID 166147502
C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n([C@H]3CCOC[C@H]3F)cc12)c1cccc(C(F)F)c1F -
(S)-N-(1-(3-chloro-4-fluorophenyl)-2,2,2-trifluoroethyl)-5-cyano-N-ethylpyridine-3-sulfonamide (Example PubChem CID 168898591
CCN(C(c1ccc(F)c(Cl)c1)C(F)(F)F)S(=O)(=O)c1cncc(C#N)c1 -
(S)-5-cyano-N-ethyl-N-(2,2,2-trifluoro-1-(4-fluoro-3-methoxyphenyl)ethyl)pyridine-3-sulfonamide (Example PubChem CID 168898755
CCN(C(c1ccc(F)c(OC)c1)C(F)(F)F)S(=O)(=O)c1cncc(C#N)c1 -
(S)-5-cyano-N-ethyl-N-(2,2,2-trifluoro-1-(4-fluoro-3-methylphenyl)ethyl)pyridine-3-sulfonamide (Example PubChem CID 169784685
CCN(C(c1ccc(F)c(C)c1)C(F)(F)F)S(=O)(=O)c1cncc(C#N)c1 -
(R)-N-(1-(3-chlorophenyl)-2,2,2-trifluoroethyl)-5-cyano-N-ethylpyridine-3-sulfonamide (Example 251) and PubChem CID 169938608
CCN(C(c1cccc(Cl)c1)C(F)(F)F)S(=O)(=O)c1cncc(C#N)c1 -
4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-6-((3R,4R)-3-fluorotetrahydro-2H-pyran-4-yl PubChem CID 170776011
COc1c(=O)n([C@@H]2CCOC[C@@H]2F)cc2c(N[C@H](C)c3cccc(C(F)F)c3F)nn(C)c(=O)c12 -
4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-6-((3R,4S)-3-fluorotetrahydro-2H-pyran-4-yl PubChem CID 170776028
COc1c(=O)n([C@H]2CCOC[C@@H]2F)cc2c(N[C@H](C)c3cccc(C(F)F)c3F)nn(C)c(=O)c12 -
4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-6-((3R,4S)-3-fluorotetrahydro-2H-pyran-4-yl PubChem CID 170776040
C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n([C@@H]3CCOC[C@H]3F)cc12)c1cccc(C(F)F)c1F -
6-[(1S,2R)-2-(5-fluoro-3-pyridyl)cyclopropyl]-2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl PubChem CID 170776080
Cc1c([C@@H](C)Nc2nn(C)c(=O)c3cc(=O)n([C@@H]4C[C@H]4c4cncc(F)c4)cc23)cccc1C(F)(F)F -
Synthesis of 2-((1S,6R)-6-(difluoromethyl)-3-azabicyclo[4.1.0]heptan-3-yl)-N-(2-(4,4-difluoropiperidin PubChem CID 170950279
Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CC[C@@]3(C(F)F)C[C@H]3C2)nc(N2CCC(F)(F)CC2)n1 -
Synthesis of 2-((1S,6R)-6-(difluoromethyl)-3-azabicyclo[4.1.0]heptan-3-yl)-N-(2-(4,4-difluoropiperidin CAS 3030452-38-8 PubChem CID 170950286
Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CC[C@]3(C(F)F)C[C@@H]3C2)nc(N2CCC(F)(F)CC2)n1 -
(R)-3-(4-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-indazol-1-yl)-3-methyldihydrofuran PubChem CID 171597661
C[C@@]1(n2ncc3c(Nc4ncc(C(F)(F)F)c(NC5CC5)n4)cccc32)CCOC1=O -
(R)-3-(4-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-indazol-1-yl)-3-methyldihydrofuran PubChem CID 171597692
C[C@]1(n2ncc3c(Nc4ncc(C(F)(F)F)c(NC5CC5)n4)cccc32)CCOC1=O -
(R)-5-cyano-N-ethyl-N-(2,2,2-trifluoro-1-(3-methyl-4-(trifluoromethyl)phenyl)ethyl)pyridine-3-sulfonamide PubChem CID 176509428
CCN([C@@H](C)c1ccc(C(F)(F)F)c(C)c1)S(=O)(=O)c1cncc(C#N)c1 -
(R)-5-fluoro-N-methyl-N-(2,2,2-trifluoro-1-(3-methyl-4-(trifluoromethyl)phenyl)ethyl)pyridine-3-sulfonamide PubChem CID 176509430
Cc1cc([C@H](C)N(C)S(=O)(=O)c2cncc(F)c2)ccc1C(F)(F)F -
Synthesis of N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-2-fluoro-4-((2-hydroxyethyl)sulfonamido PubChem CID 176797685
CCOC(=O)CS(=O)(=O)Nc1cc(F)c(C(=O)Oc2cc(C)nc(N3CCC(F)(F)CC3)n2)c(N2CC[C@]3(C)C[C@@H]3C2)c1 -
Synthesis of N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-2-fluoro-4-((2-hydroxyethyl)sulfonamido PubChem CID 177373167
CCOC(=O)CS(=O)(=O)Nc1cc(F)c(C(=O)Oc2cc(C)nc(N3CCC(F)(F)CC3)n2)c(N2CC[C@@]3(C)C[C@@H]3C2)c1 -
N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-4-((2-hydroxyethyl)sulfonamido)-2-((1S,6R)- PubChem CID 177373170
CCOC(=O)CS(=O)(=O)Nc1ccc(C(=O)Nc2cc(C)nc(N3CCC(F)(F)CC3)n2)c(N2CC[C@@]3(COC)CC3C2)c1 -
N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-4-((2-hydroxyethyl)sulfonamido)-2-((1S,6R)- PubChem CID 177373171
CCOC(=O)CS(=O)(=O)Nc1ccc(C(=O)Nc2cc(C)nc(N3CCC(F)(F)CC3)n2)c(N2CC[C@]3(COC)CC3C2)c1 -
(S)-N-ethyl-5-morpholino-N-(2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)pyridine-3-sulfonamide (Example 95 PubChem CID 168898623
CCN(C(c1ccc(F)cc1)C(F)(F)F)S(=O)(=O)c1cncc(N2CCOCC2)c1