Example+4-1 - 化合物搜索

Example 29-A. PubChem CID 118627986

CCOC(=O)N1CCC(c2ccc(O[C@H]3CCc4cccc(-c5cccc(-n6ncc(C(=O)O)c6CC)n5)c43)cc2CC)CC1

Example 14-A. tert-Butyl 4-(4-((7-(6-(4-(ethoxycarbonyl)-5-ethyl)-1H-pyrazol-1-yl)pyridin-2-yl)indolin PubChem CID 118627913

CCc1cc(CN2CCc3cccc(-c4cccc(-n5ncc(C(=O)O)c5CC)n4)c32)ccc1C1CCN(C(=O)C2CC2)CC1

Example 15-A. PubChem CID 118628094

CCc1cc(CN2CCc3cccc(-c4cccc(-n5ncc(C(=O)O)c5C(F)(F)F)n4)c32)ccc1C1CCN(CC(F)(F)F)CC1

Example 56-A. a). (+-)-tert-Butyl 4-(4-((7-(3-(4-(ethoxycarbonyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl PubChem CID 130199941

Cc1cc(C2CCN(C(=O)CO)CC2)ccc1NC1CCc2cccc(-c3cccc(-n4ncc(C(=O)O)c4C(F)(F)F)c3)c21

Example 12-A. tert-Butyl 4-(4-((7-(6-(4-(ethoxycarbonyl)-6-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin- PubChem CID 130211485

CCOC(=O)c1cnn(-c2cccc(-c3cccc4c3N(Cc3ccc(C5CCN(C(=O)OC(C)(C)C)CC5)cc3)CC4)n2)c1C(F)(F)F

Example 13-A. tert-Butyl 4-(4-((7-(6-(4-(ethoxycarbonyl)-6-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin- PubChem CID 130211486

CCOC(=O)c1cnn(-c2cccc(-c3cccc4c3N(Cc3ccc(C5CCN(C(=O)OC(C)(C)C)CC5)c(CC)c3)CC4)n2)c1C(F)(F)F

Example 28-A. PubChem CID 141657036

CCc1cc(Cn2cc(C)c3cccc(-c4cccc(-n5ncc(C(=O)O)c5F)n4)c32)ccc1C1CCN(C(=O)C2CC2)CC1

N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)-1-((R)-2,2- dimethyltetrahydro-2H-pyran-4-yl)-4-(( PubChem CID 169321579

C[C@@H](NC(=O)c1cn([C@@H]2CCOC(C)(C)C2)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F

N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)-1-(1- (difluoromethyl)cyclopropyl)-4-(((S)-4-methyl PubChem CID 169321736

C[C@@H](NC(=O)c1cn(C2(C(F)F)CC2)c(=O)cc1N[C@@H]1CCN(C)C2(CC2)C1)c1cccc(C(F)F)c1F

4-methyl-1- [1-methyl-3-(4- methylsulfonyl- piperazin- 1-yl)propyl]-5-[[2-[6- (2,2,2-trifluoroethyl) PubChem CID 172395706

Cc1c(CN2CCC3(CC2)CN(c2ncnc4ccc(CC(F)(F)F)cc24)C3)ccc2c1cc(C#N)n2C(C)CCN1CCN(S(C)(=O)=O)CC1

4-methyl-1-[1- methyl-2-(4- methylsulfonyl- piperazin- 1-yl)ethyl]-5-[[2-[6- (2,2,2-trifluoroethyl) quinazolin PubChem CID 172395710

Cc1c(CN2CCC3(CC2)CN(c2ncnc4ccc(CC(F)(F)F)cc24)C3)ccc2c1cc(C#N)n2C(C)CN1CCN(S(C)(=O)=O)CC1

4-methyl-1-[(1R)- 1-methyl-2-(4- methylsulfonyl- piperazin- 1-yl)ethyl]-5-[[2-[6- (2,2,2-trifluoroethyl PubChem CID 172395737

Cc1c(CN2CCC3(CC2)CN(c2ncnc4ccc(CC(F)(F)F)cc24)C3)ccc2c1cc(C#N)n2[C@H](C)CN1CCN(S(C)(=O)=O)CC1

4-methyl-1-[(1S)- 1-methyl-2-(4- methylsulfonyl- piperazin- 1-ylethyl]-5-[[2-[6- (2,2,2-trifluoroethyl PubChem CID 172395776

Cc1c(CN2CCC3(CC2)CN(c2ncnc4ccc(CC(F)(F)F)cc24)C3)ccc2c1cc(C#N)n2[C@@H](C)CN1CCN(S(C)(=O)=O)CC1

4-methoxy-1- [1-methyl-2-(4- methylsulfonyl- piperazin- 1-yl)ethyl]-5-[[2-[6- (2,2,2-trifluoroethyl) PubChem CID 176734125

COc1c(CN2CCC3(CC2)CN(c2ncnc4ccc(CC(F)(F)F)cc24)C3)ccc2c1cc(C#N)n2C(C)CN1CCN(S(C)=O)CC1

N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)-1x-((S)-1- (1-fluorocyclopropane-1-carbonyl)-3-methylpyrrolidin PubChem CID 169127045

C[C@@H](NC(=O)c1cn([C@@]2(C)CCN(C(=O)C3(F)CC3)C2)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F

(6-(4-(1H-pyrazol-1-yl)phenyl)-4-(2-(((1R,2S)-2-(4-fluorophenyl)cyclopropyl)amino)ethyl)pyrid in-2-yl PubChem CID 165141426

CS(=O)(=O)N1CCN(C(=O)c2cc(CCN[C@@H]3C[C@H]3c3ccc(F)cc3)cc(-c3ccc(-n4cccn4)cc3)n2)CC1

US9526727, Comparison Example Table 2, (1r,1'R,4R)-2''-amino-6'-(2-cyclopropylethyl)-4-methoxy-1''-[( PubChem CID 58197558

COC1CCC2(CC1)Cc1ccc(CCC3CC3)cc1[C@]21N=C(N)N(C[C@@H]2CCO2)C1=O

Example 104: 4-([(1S,2S)-2-[(R)-3-Aminopiperidin-1-yl]-1,6-dichloro-2,3-dihydro-1H-inden-1-yl]oxy)-N- PubChem CID 153283863

N[C@@H]1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c3ccc(O[C@H]4c5cc(Cl)cc(Cl)c5C[C@@H]4N4CCC[C@@H](N)C4)cc3Cl)c(Cl)c2)C1

Example 19A methyl (1r,4r)-4-(3-bromoanilino)-1'-methyl-2'-oxo-5'-[(1E)-3-phenylprop-1-en-1-yl]-1',2' PubChem CID 164583520

CN1C(=O)C2(CCC(Nc3cccc(Br)c3)(C(=O)O)CC2)c2cc(/C=C/Cc3ccccc3)ccc21

1-((S)-1-acetyl-3-methylpyrrolidin-3-yl)-N-((R)-1-(3- (difluoromethyl)-2-fluorophenyl)ethyl)-4-((1-methylpiperidin PubChem CID 169126903

CC(=O)N1CC[C@](C)(n2cc(C(=O)N[C@H](C)c3cccc(C(F)F)c3F)c(NC3CCN(C)CC3)cc2=O)C1

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