Example+3-2 - 化合物搜索

1-((1S,2R)-[1,1'-bi(cyclopropan)]-2-yl)-N-((R)-1-(3- (difluoromethyl)-2-fluorophenyl)ethyl)-4-(((1R5S PubChem CID 169321725

C[C@@H](NC(=O)c1cn([C@H]2C[C@@H]2C2CC2)c(=O)cc1NC1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F

(S)-1,1,1-trifluoro-2-methylpropan-2-yl(4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-2-(2-(4-methyl PubChem CID 118187659

CCn1cc(S(=O)(=O)N2C[C@H](CCc3n[nH]c(=O)n3C)Oc3ccc(NC(=O)OC(C)(C)C(F)(F)F)cc32)c(Cl)n1

2-{3-Methyl-1-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]-1H-pyrazol PubChem CID 121314074

Cc1nn([C@@H]2CC[C@@H](C)N(C(=O)c3ccccc3-n3nccn3)C2)cc1C(C)(C)O

Example 104: 4-([(1S,2S)-2-[(R)-3-Aminopiperidin-1-yl]-1,6-dichloro-2,3-dihydro-1H-inden-1-yl]oxy)-N- PubChem CID 153283863

N[C@@H]1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c3ccc(O[C@H]4c5cc(Cl)cc(Cl)c5C[C@@H]4N4CCC[C@@H](N)C4)cc3Cl)c(Cl)c2)C1

Example 174A methyl (1r,4r)-4-(3-chloroanilino)-2'-{2-[(2-fluoropyridin-4-yl)oxy]ethyl}-2',3'-dihydrospiro PubChem CID 164581924

COc1cc(OCCC2Cc3ccccc3C23CCC(Nc2cccc(Cl)c2)(C(=O)O)CC3)ccn1

Example 703A (2'R)-2'-[(2R)-3-hydroxy-2-methylpropyl]-2',3'-dihydrospiro[cyclohexane-1,1'-inden]-4-one PubChem CID 164582227

C[C@@H](COc1ccnc2c1[C@H](C)CCC2)C[C@@H]1Cc2ccccc2C12CCC(Nc1ccc(F)c(Cl)c1)(C(=O)O)CC2

Example 848A methyl (1r,4S,6'S)-4-(3-chloroanilino)-6'-[(2R)-3-hydroxy-2-methylpropyl]-2',2'-dimethyl PubChem CID 164583270

C[C@@H](COc1ccnc2c1[C@H](C)CCC2)C[C@H]1Cc2cc3c(cc2C12CCC(Nc1cccc(Cl)c1)(C(=O)O)CC2)OC(C)(C)O3

Example 714A (1'S,1″r,2″S)-2″-[(2R)-3-hydroxy-2-methylpropyl]-2″,3″-dihydrodispiro PubChem CID 164583567

C[C@@H](COc1ccnc2c1[C@H](C)CCC2)C[C@H]1Cc2ccccc2C12CCC(Nc1ccnc(Cl)c1)(C(=O)O)CC2

Example 757A methyl (1r,4r)-4-[N-(3-chlorophenyl)-2,2,2-trifluoroacetamido]-2'-[(2R)-3-hydroxy-2-methylpropyl PubChem CID 171918517

CC(=O)c1cc(C)c2c(c1)C1(CCC(Nc3cccc(Cl)c3)(C(=O)O)CC1)[C@@H](C[C@@H](C)COc1ccnc3c1[C@H](C)CCC3)C2

US10227334, Example (S)-3-(3-Hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1- yl)propoxy PubChem CID 54766177

CC1=C(c2cccc(O)c2)[C@H](c2ccc(OC[C@H](C)N3CC[C@@H](C)C3)cc2)Oc2ccc(O)cc21

US10227334, Example 2-(4-((S)-2-((R)-3-fluoropyrrolidin-1-yl)propoxy)phenyl)-3-(3-hydroxyphenyl)-4- methyl PubChem CID 54767766

CC1=C(c2cccc(O)c2)C(c2ccc(OC[C@H](C)N3CC[C@@H](F)C3)cc2)Oc2ccc(O)cc21

Example 388 Preparation of 1- (5- (1,3-difluoro-2- methylpropan-2- yl) isoxazol-3-yl)-3- (3- (7-ethoxy PubChem CID 58267747

CCOc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(C(C)(CF)CF)on4)c3)c2cc1OC

US9670208, Example 132 4-(3-(1-((5-fluoro-2-methoxypyridin-3-yl)methyl)piperidin-3-yl)-[1,2,4]triazolo PubChem CID 118216803

COc1ncc(F)cc1CN1CCCC(c2nnc3cc(-c4ccnc(NC5CCOCC5)n4)ccn23)C1

7-(4-(isopropylamino)-5-(5-((1r,3r)-3-(oxetan-3-ylamino)cyclobutyl)-1,3,4-thiadiazol-2-yl)pyridin-2-yl PubChem CID 146393370

CC(C)Nc1cc(-c2ccc3cc(C#N)cnn23)ncc1-c1nnc(C2CC(NC3COC3)C2)s1

First-eluting enantiomer from separation of Example 9 (see footnote 5 in Table 1); 2-{5-[(3-ethoxypyridin PubChem CID 156207597

CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)NC3CCC(C(F)(F)F)NC3)cn2)c1

Example 450A methyl (1r,4r)-4-(3-chloroanilino)-2'-{3-[(pyrimidin-5-yl)oxy]propyl}-2',3'-dihydrospiro PubChem CID 164581927

O=C(O)C1(Nc2cccc(Cl)c2)CCC2(CC1)c1ccccc1CC2CCCOc1cncnc1

Example 475A methyl (1r,4r)-4-(3-chloroanilino)-2'-{3-[(7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin PubChem CID 164582049

COC(=O)C1(Nc2cccc(Cl)c2)CCC2(CC1)c1ccccc1CC2CCCOc1ccnc2c1CCC2O

Example 451A methyl (1r,4r)-4-(3-chloroanilino)-2'-{3-[(pyrimidin-5-yl)oxy]propyl}-2',3'-dihydrospiro PubChem CID 164582133

COC(=O)C1(Nc2cccc(Cl)c2)CCC2(CC1)c1ccccc1CC2CCCOc1ccnc2c1CCCC2

Example 425A methyl (1r,4r)-4-(3-chloroanilino)-2'-[3-(4-fluorophenoxy)propyl]-2',3'-dihydrospiro[cyclohexane PubChem CID 164582176

O=C(O)C1(Nc2cccc(Cl)c2)CCC2(CC1)c1ccccc1CC2CCCOc1ccc(F)cc1

Example 502A methyl (1r,4r)-4-(3-chloroanilino)-2'-(3-oxopropyl)-2',3'-dihydrospiro[cyclohexane-1,1'- PubChem CID 164582297

COCC(F)(F)CC1Cc2ccccc2C12CCC(Nc1cccc(Cl)c1)(C(=O)O)CC2

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