Example+3-2 - 化合物搜索

4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-6-((S)-6,6-difluorospiro[2.5]octan-1-yl)-2- PubChem CID 166147498

C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n([C@@H]3CC34CCC(F)(F)CC4)cc12)c1cccc(C(F)F)c1F

6-((S)-3,3-difluorocyclopentyl)-4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-2-methylpyrido PubChem CID 166147561

C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n([C@@H]3CCC(F)(F)C3)cc12)c1cccc(C(F)F)c1F

4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-6-((R)-2,2-dimethylcyclopropyl)-2-methyl-2,6 PubChem CID 166147644

C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n([C@H]3CC3(C)C)cc12)c1cccc(C(F)F)c1F

4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-2-methyl-6-((R)-spiro[2.2]pentan-1-yl)-2,6- PubChem CID 166147730

C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n([C@H]3CC34CC4)cc12)c1cccc(C(F)F)c1F

4-(((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-6-((S)-2,2-dimethyltetrahydro-2H-pyran-4-yl PubChem CID 170776085

C[C@@H](Nc1nn(C)c(=O)c2cc(=O)n([C@H]3CCOC(C)(C)C3)cc12)c1cccc(C(F)F)c1F

(R)-6-(1-((6-cyclopropyl-2-methyl-1,7-dioxo-1,2,6,7-tetrahydropyrido[3,4-d]pyridazin-4-yl)amino)ethyl PubChem CID 166147418

C[C@H](Nc1nn(C)c(=O)c2cc(=O)n(C3CC3)cc12)c1ccc2c(C#N)nn(C)c2c1

6-cyclopropyl-2-methyl-4-[[(1S)-1-[3-methyl-5-(trifluoromethyl)phenyl]ethyl]amino]pyrido[3,4-d]pyridazine PubChem CID 166147480

Cc1cc([C@H](C)Nc2nn(C)c(=O)c3cc(=O)n(C4CC4)cc23)cc(C(F)(F)F)c1

(R)-5-Cyano-N-ethyl-N-(2,2,2-trifluoro-1-(2-fluorophenyl)ethyl)pyridine-3-sulfonamide (Example 116) and PubChem CID 169728459

CCN(C(c1ccccc1F)C(F)(F)F)S(=O)(=O)c1cncc(C#N)c1

(S)-5-cyano-N-ethyl-N-(2,2,2-trifluoro-1-(2-(trifluoromethyl)phenyl)ethyl)pyridine-3-sulfonamide (Example PubChem CID 169786356

CCN(C(c1ccccc1C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cncc(C#N)c1

(R)-6-(1-((6-cyclopropyl-2-methyl-1,7-dioxo-1,2,6,7-tetrahydropyrido[3,4-d]pyridazin-4-yl)amino)ethyl PubChem CID 170776070

Cc1cc([C@H](C)Nc2nn(C)c(=O)c3cc(=O)n(C4CC4)cc23)cc2c1c(C#N)nn2C

3-{[4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin PubChem CID 121397299

Cc1cnc(-c2cc(OCC3CN(C)CCO3)cc(C(=O)N[C@H](C)c3cnc(C(F)(F)F)nc3)c2)s1

3-(5-Methyl-1,3-thiazol-2-yl)-5-[morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl] PubChem CID 121397625

Cc1cnc(-c2cc(OCC3CNCCO3)cc(C(=O)N[C@H](C)c3cnc(C(F)(F)F)nc3)c2)s1

(S)-N-ethyl-5-morpholino-N-(2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)pyridine-3-sulfonamide (Example 95 PubChem CID 168898623

CCN(C(c1ccc(F)cc1)C(F)(F)F)S(=O)(=O)c1cncc(N2CCOCC2)c1

(S)-N-ethyl-5-(pyrrolidin-1-yl)-N-(2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)pyridine-3-sulfonamide (Example PubChem CID 168899162

CCN(C(c1ccc(F)cc1)C(F)(F)F)S(=O)(=O)c1cncc(N2CCCC2)c1

(R)-N-ethyl-N-(2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)imidazo[1,2-a]pyridine-2-sulfonamide (Example PubChem CID 176509360

CCN([C@@H](C)c1ccc(F)cc1)S(=O)(=O)c1cn2ccccc2n1

Preparation of 2-(pentan-3-yloxy)-6-((1-(thiazole-2-yl)piperidine-4-yl)amino)pyrimidine-4-carboxylic PubChem CID 177373207

CC(=O)N1CCC(Nc2cc(C(=O)N3CC[C@@H](N4CCc5ccccc5C4)[C@H](O)C3)nc(-c3cccc(F)c3F)n2)CC1

Preparation of ((3R,4R)-4-(3,4-dihydroisoquinoline-2(1H)-yl)-3-hydroxypiperidine-1-yl)(2-isopropoxy-6 PubChem CID 177373208

CC(=O)N1CCC(Nc2cc(C(=O)N3CC[C@@H](N4CCc5ccccc5C4)[C@H](O)C3)nc(-c3ccc(F)c(F)c3)n2)CC1

Preparation of 6-((3-(N-methylacetylamido)propyl)amino)-2-phenylpyrimidine-4-carboxylic acid (for example PubChem CID 176799636

CC(=O)N1CCC(Nc2cc(C(=O)N3CC[C@@H](N4CCc5ccccc5C4)[C@H](O)C3)nc(-c3ccccc3F)n2)CC1

Preparation of trans-(1-(6-((1-acetylpiperidine-4-yl)amino)pyrimidine-4-carbonyl)-4-(3,4-dihydroisoquinoline-2( PubChem CID 177373199

CCNc1cc(C(=O)N2CCC(N3CCc4ccccc4C3)[C@H](O)C2)nc(-c2ccccc2)n1

Example 78: 3-[2-(2-[2-[(4-[[(1S,2S)-4,6-Dichloro-2-[(3R)-3-[methyl(propan-2-yl)amino]piperidin-1-yl] PubChem CID 156403359

CC(C)N(C)[C@@H]1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c3ccc(O[C@H]4c5cc(Cl)cc(Cl)c5C[C@@H]4N4CCC[C@@H](N(C)C(C)C)C4)cc3)cc2)C1

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