Example+10-17 - 化合物搜索

4-{(7S,10S,13S)-10-(4-aminobutyl)-7-(3-aminopropyl)-13-[(1H-indol-3-yl)methyl]-12-methyl-8,11,14-trioxo-5,6,7,8,9,10,11,12,13,14,15,16-dodecahydropyrido[2,3-b][1,5,8,11,14]benzothiatetraazacycloheptadecin-17-yl}benzoic acid CAS 2379336-76-0 PubChem CID 148636827

CN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN)NCc2cccnc2Sc2cccc(-c3ccc(C(=O)O)cc3)c2CNC(=O)[C@@H]1Cc1c[nH]c2ccccc12

US10654860, Example 10 PubChem CID 155490047

COc1cccc(NC2CCN(c3ccc4c(c3)OCC3NNCC43)C2=O)c1

4-(11-cyclopropyl-10-oxo-1,6,11-triazatricyclo[7.4.0.02,7]trideca-2(7),3,5,8-tetraen-8-yl)-2-fluorobenzonitrile CAS 2055776-17-3 PubChem CID 124141261

N#Cc1ccc(-c2c3n(c4cccnc24)CCN(C2CC2)C3=O)cc1F

(1S,12'S)-6-CHLORO-12'-HYDROXY-9'-METHYL-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,19'-[17]OXA[10]THIA[1,9]DIAZATRICYCLO[11.7.2.016,21]DOCOSA[13,15,21]TRIENE]-12'-CARBOXYLIC ACID 10',10'-DIOXIDE PubChem CID 153341198

CN1CCCCCCCN2C[C@@]3(CCCc4cc(Cl)ccc43)COc3ccc(cc32)[C@](O)(C(=O)O)CS1(=O)=O

(1S,6'E,12'S)-6-CHLORO-12'-HYDROXY-9'-METHYL-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,19'-[17]OXA[10]THIA[1,9]DIAZATRICYCLO[11.7.2.016,21]DOCOSA[6,13,15,21]TETRAENE]-12'-CARBOXYLIC ACID 10',10'-DIOXIDE PubChem CID 156064961

CN1C/C=C/CCCCN2C[C@@]3(CCCc4cc(Cl)ccc43)COc3ccc(cc32)[C@](O)(C(=O)O)CS1(=O)=O

Synthesis of 1-((3R,5R,8S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-2,3,4,5,6,7,8,10,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(5-methyl-2H-tetrazol-2-yl)ethan-1-one (A20) & 1-((3R,5R,8S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-2,3,4,5,6,7,8,10,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(5-methyl-1H-tetrazol-1-yl)ethan-1-one (A21) PubChem CID 146522515

Cc1nnn(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@]5(C)C4=CC[C@]23C)n1

Preparation of (11R,13S,17R)-17-Acetyl-11-(4-((6-(4-(((S)-10-((dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)piperidin-1-yl)hexyl)(methyl)amino)phenyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate PubChem CID 165146167

CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CN(C)C)c(OC4CCN(CCCCCCN(C)c5ccc([C@H]6C[C@@]7(C)C(CC[C@]7(OC(C)=O)C(C)=O)C7CCC8=CC(=O)CCC8=C76)cc5)CC4)ccc3nc2-1

Synthesis of (S)-10-((dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 4-(6-((4-((8S,11R,13S,14S,17R)-17-acetoxy-17-acetyl-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)phenyl)(methyl)amino)hexyl)piperazine-1-carboxylate PubChem CID 166011518

CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CN(C)C)c(OC(=O)N4CCN(CCCCCCN(C)c5ccc([C@H]6C[C@@]7(C)[C@@H](CC[C@]7(OC(C)=O)C(C)=O)[C@@H]7CCC8=CC(=O)CCC8=C76)cc5)CC4)ccc3nc2-1

4-[(4R,7S,8R)-17-({[(7aS)-2-(difluoromethylene)-2,3,5,6,7,7a-hexahydro-1H-pyrrolizin-7a-yl]methyl}oxy)-14-fluoro-10-methylidene-12-(trifluoromethyl)-2,16,18,20-tetrazapentacyclo[13.3.1.14,7.011'19.02'8]icosa-1(19),1(12),13,15(16),17-pentaen-13-yl]-2- amino-7-fluorobenzo [b] thiophene-3-carbonitrile PubChem CID 177858555

C=C1C[C@@H]2[C@H]3CC[C@@H](CN2c2nc(OC[C@@]45CCCN4CC(=C(F)F)C5)nc4c(F)c(-c5ccc(F)c6c5C(C#N)C(N)S6)c(C(F)(F)F)c1c24)N3

(rac)-4-chloro-12-(2,2-difluoroethyl)-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3',4':8,9][1,4]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid PubChem CID 142591239

CCc1c2c(nn1C)CCCN(CC(F)F)CCn1c(C(=O)O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c31

2-Propen-1-one, 1-((3S)-4-((7R)-7-(6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl)-6-chloro-8-fluoro-2-(((2S)-1-methyl-2-pyrrolidinyl)methoxy)-4-quinazolinyl)-3-methyl-1-piperazinyl)- CAS 2417987-45-0 PubChem CID 146624881

C=CC(=O)N1CCN(c2nc(OC[C@@H]3CCCN3C)nc3c(F)c(-c4nc(N)cc(C)c4C(F)(F)F)c(Cl)cc23)[C@@H](C)C1

(1S,6'E,12'R)-6-CHLORO-9'-METHYL-10'-OXO-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,19'-[17]OXA[1,9]DIAZATRICYCLO[11.7.2.016,21]DOCOSA[6,13,15,21]TETRAENE]-12'-CARBOXYLIC ACID PubChem CID 153341386

CN1C/C=C/CCCCN2C[C@@]3(CCCc4cc(Cl)ccc43)COc3ccc(cc32)C(C(=O)O)CC1=O

(1S,6'E)-6-CHLORO-9'-CYCLOPROPYL-12'R-HYDROXY-10'-OXO-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,19'-[17]OXA[1,9]DIAZATRICYCLO[11.7.2.016,21]DOCOSA [6,13,15,21]TETRAENE]-12'-CARBOXYLIC ACID PubChem CID 156078880

O=C1CC(O)(C(=O)O)c2ccc3c(c2)N(CCCC/C=C/CN1C1CC1)C[C@@]1(CCCc2cc(Cl)ccc21)CO3

(1S,6'E,11'R,12'S)-6-CHLORO-12'-HYDROXY-9',11'-DIMETHYL-10'-OXO-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,19'-[17]OXA[1,9]DIAZATRICYCLO[11.7.2.016,21]DOCOSA[6,13,15,21]TETRAENE]-12'-CARBOXYLIC ACID PubChem CID 156622636

C[C@H]1C(=O)N(C)C/C=C/CCCCN2C[C@@]3(CCCc4cc(Cl)ccc43)COc3ccc(cc32)[C@H]1O

(E)-N,N,10-trimethyl-3,5-dioxo-12,13-dihydro-11H-2,6-diaza-1(2,1)-benzo[d]imidazola-4(1,3)-benzenacycloundecaphane-17-carboxamide PubChem CID 172122551

C[C@H]1CCCCNC(=O)c2cccc(c2)C(=O)Nc2nc3ccc(Cl)c(C(=O)N(C)C)c3n21

7-[(3R,4S,6S,10R)-4-Benzyl-2-oxa-7,13,14-triazatetracyclo[14.3.1.13,6.111,1 4 ]docosa-1(19),11(21),12,16(20),17-pentaen-10-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine PubChem CID 138712432

Nc1cc([C@H]2CCN[C@H]3C[C@H](Cc4ccccc4)[C@@H](C3)Oc3cccc(c3)Cn3cc2cn3)c2n[nH]nc2n1

3-((2R)-2,3-dihydroxypropyl)-6-fluoro-5-((2-fluoro-4-iodophenyl)amino)-8-methyl-3H,4H,7H,8H-pyrido(2,3-d)pyrimidine-4,7-dione CAS 1035555-63-5 PubChem CID 24963252

Cn1c(=O)c(F)c(Nc2ccc(I)cc2F)c2c(=O)n(C[C@@H](O)CO)cnc21

4- {[(1R,2R,5R,10S,13R,14R, 17S,19R)-5-(2-{[(4- chlorophenyl)methyl][2- (dimethylamino)ethyl] amino}ethyl)-1,2,14,18,18- pentamethyl-7-oxo-8- (propan-2- yl)pentacyclo[11.8.0.0{circumflex over ()} {2,10}.0{circumflex over ()}{5,9}.0{circumflex over ()}{14,19}] henicos-8-en-17-yl]oxy}- 2,2-dimethyl-4- oxobutanoic acid PubChem CID 71614327

CC(C)C1=C2[C@H]3CC[C@@H]4[C@@]5(C)CC[C@H](OC(=O)CC(C)(C)C(=O)O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]2(CCN(CCN(C)C)Cc2ccc(Cl)cc2)CC1=O

(2S)-2-(tert-Butoxy)-2-[(22S)-4,22,28-trimethyl-17-(trifluoromethyl)-21,27-dioxa-1,5,7,8-tetraazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34), 8, 10(33), 11, 13, 15 (20),16,18-decaen-3-yl]acetic acid PubChem CID 86710796

Cc1nc2cc3nn2c(c1[C@H](OC(C)(C)C)C(=O)O)N1CCC(C)(CC1)OCCCC[C@H](C)Oc1ccc(C(F)(F)F)cc1-c1cccc-3c1

2-[1-[(5-Methoxy-7-methyl-1H-indol-4-yl)methyl]-2-piperidinyl]-4-methyl-5-thiazolecarboxylic acid CAS 1644670-10-9 PubChem CID 90466600

COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1nc(C)c(C(=O)O)s1

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