Chemical Compound

Laroprovstat

CAS Registry Number 2455427-91-3
Back to search Request a Quote
Laroprovstat chemical structure
Primary Record

Laroprovstat

In stock
6,474 g
Purity
99.2 %
CAS
2455427-91-3

Compound Identifiers & Properties

CAS
2455427-91-3
PubChem CID
154653847
SMILES
C1C[C@@H](C[C@H]1NC2=NC=C(C=C2)N3C=CC=CC3=O)NC4=NC=C(C=N4)OC(F)F
Canonical SMILES
O=c1ccccn1-c1ccc(N[C@H]2CC[C@H](Nc3ncc(OC(F)F)cn3)C2)nc1

Names & Synonyms

  • Laroprovstat
  • PCSK9-IN-12
  • AZD0780
  • laroprovstat [INN]
  • 9EEL3YMY29
  • RefChem:1088363
  • 2455427-91-3
  • LAROPROVSTAT [USAN]
  • AZD-0780
  • orb1685685
  • CHEMBL5404296
  • SCHEMBL22241911
  • GTPL13419
  • AZD 0780 [WHO-DD]
  • NCHUWRLOTSAFFN-KBPBESRZSA-N
  • BDBM537931
  • DGM-1656
  • EX-A6975
  • US11248001, Example 458B
  • example 458B [US11248001B2]
  • AC-38192
  • DA-76642
  • MS-27171
  • HY-148673
  • AZ14232880
  • CS-0636856
  • AZ-14232880
  • CR000501656
  • CR-000501656
  • H38166
  • A1244091
  • 6'-(((1S,3S)-3-((5-(Difluoromethoxy)pyrimidin-2-yl)amino)cyclopentyl)amino)-2H-[1,3'-bipyridin]-2-one
  • 1-[6-[[(1S,3S)-3-[[5-(difluoromethoxy)pyrimidin-2-yl]amino]cyclopentyl]amino]pyridin-3-yl]pyridin-2-one
  • 6'-[[(1S,3S)-3-[[5-(Difluoromethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2H),3'-bipyridin]-2-one
  • (1(2H),3'-BIPYRIDIN)-2-ONE, 6'-(((1S,3S)-3-((5-(DIFLUOROMETHOXY)-2-PYRIMIDINYL)AMINO)CYCLOPENTYL)AMINO)-
  • 1-(6-((1S,3S)-3-(5-(Difluoromethoxy)pyrimidin-2-ylamino)cyclopentylamino)pyridin-3-yl)pyridin-2(1H)-one
  • 6'-{[(1S,3S)-3-{[5-(difluoromethoxy)pyrimidin-2-yl]amino}cyclopentyl]amino}-2H-[1,3'-bipyridin]-2-one
Custom Synthesis

Laroprovstat Custom Synthesis Services

Explore custom synthesis capabilities for Laroprovstat (AZD0780), including chiral building blocks, fluorinated heterocycles, key intermediates, related substances and analytical reference materials. Custom requirements and specifications can be discussed with our team.

Core Molecule & API Synthesis

Custom synthesis and route development for Laroprovstat (AZD0780), a small-molecule PCSK9 inhibitor.

  • Laroprovstat (AZD0780) Custom Synthesis
  • Synthetic Route Scouting
  • Route Optimization
  • Process Development
  • Scale-Up and Process Transfer

Chiral Building Blocks & Intermediates

Custom synthesis of stereochemically defined cyclopentane and amine building blocks relevant to Laroprovstat.

  • (1S,3S)-Cyclopentane-1,3-Diamine Derivatives
  • Chiral Cyclopentane Intermediates
  • Enantiomeric Building Blocks
  • Protected Chiral Diamines
  • Stereochemistry-Controlled Intermediates
  • (1S,3S)-N1-(5-(Difluoromethoxy)pyrimidin-2-yl)cyclopentane-1,3-diamine Intermediate (CAS 2455427-29-7)

Heterocyclic Building Blocks

Custom synthesis of substituted pyridine, pyridone and pyrimidine building blocks.

  • Substituted Pyridine Building Blocks
  • Pyridone Derivatives
  • Aminopyrimidine Derivatives
  • Substituted Pyrimidines
  • Heteroaryl Amine Intermediates

Fluorinated Building Blocks

Custom synthesis of fluorinated heterocycles and difluoromethoxy-containing intermediates.

  • Difluoromethoxy Pyrimidine Intermediates
  • Difluoromethyl Ether Building Blocks
  • Fluorinated Heteroaryl Intermediates
  • Fluorinated Amine Building Blocks

Key Synthetic Intermediates

Custom synthesis of protected and advanced intermediates for small-molecule assembly.

  • Cyclopentyl Diamine Intermediates
  • Pyrimidinyl Amino Intermediates
  • Aminopyridyl Pyridone Intermediates
  • Protected Amine Intermediates
  • Late-Stage Synthetic Intermediates

Analogs & Structure–Activity Relationship Compounds

Custom synthesis of Laroprovstat-related analogs and molecular probes for structure–activity relationship research.

  • Heteroaryl Ring Analogs
  • Pyridone Ring Modifications
  • Pyrimidine Substitution Variants
  • Difluoromethoxy Group Analogs
  • Cyclopentane Stereoisomers
  • Positional Isomers

Related Substances & Process Impurities

Custom synthesis of specified process-related impurities and structurally characterized related substances.

  • Starting Material-Related Impurities
  • Intermediate-Related Impurities
  • Regioisomeric Impurities
  • Stereoisomeric Impurities
  • Residual Coupling-Related Impurities
  • Process-Related Byproducts

Metabolites & Degradation Products

Custom synthesis of identified or proposed Laroprovstat metabolites and degradation products for analytical research.

  • Oxidative Metabolite Standards
  • Hydrolytic Degradation Products
  • Photolytic Degradation Products
  • Thermal Degradation Products
  • Metabolite Reference Materials

Stable Isotope-Labeled Compounds

Custom synthesis of isotope-labeled Laroprovstat and related small molecules for analytical and research applications.

  • 13C-Labeled Laroprovstat
  • 15N-Labeled Laroprovstat
  • Deuterium-Labeled Laroprovstat
  • Multi-Isotope-Labeled Analogs
  • Isotope-Labeled Internal Standards

Reference Standards & Analytical Materials

Custom synthesis of analytical reference materials for Laroprovstat-related testing and method development.

  • Laroprovstat Reference Standard
  • Working Standards
  • Related Substance Reference Standards
  • Impurity Reference Standards
  • System Suitability Standards
  • Analytical Method Development Standards

Solid-State Forms & Material Characterization

Research support for evaluating solid-state forms and material attributes where scientifically appropriate.

  • Polymorph Screening Materials
  • Solvate and Hydrate Studies
  • Crystallization Screening
  • Solid-State Characterization Samples