Chemical Compound

Humanized mouse monoclonal immunoglobulin G1 anti-(human CD70 antigen) linked via thioether bonds to an average of 3 to 5 molecules of mafodotin: tetrakis(SCys- ((3RS)-1-(6-(((1S)-1-(((1S)-1-(((1S,2R)-4-((2S)-2-((1R,3R)-3-(((1S)-1-carboxy-2- phenylethyl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-2-methoxy-1-((1S)- 1-methylpropyl)-4-oxobutyl)methylcarbamoyl)-2-methylpropyl)carbamoyl)-2- methylpropyl)methylamino)-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl))immunoglobulin G1, anti-(human CD70 antigen (CD27 ligand, tumor necrosis factor ligand superfamily member 7)); humanized mouse monoclonal h1F6 gamma heavy chain (221-218')-disulfide with humanized mouse monoclonal h1F6 kappa light chain dimer (227-227'':230-230'')- bisdisulfide

Brand: EASY CDMO
SKU: 86278355

CAS Registry Number 1160590-05-5

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Primary record

Humanized mouse monoclonal immunoglobulin G1 anti-(human CD70 antigen) linked via thioether bonds to an average of 3 to 5 molecules of mafodotin: tetrakis(SCys- ((3RS)-1-(6-(((1S)-1-(((1S)-1-(((1S,2R)-4-((2S)-2-((1R,3R)-3-(((1S)-1-carboxy-2- phenylethyl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-2-methoxy-1-((1S)- 1-methylpropyl)-4-oxobutyl)methylcarbamoyl)-2-methylpropyl)carbamoyl)-2- methylpropyl)methylamino)-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl))immunoglobulin G1, anti-(human CD70 antigen (CD27 ligand, tumor necrosis factor ligand superfamily member 7)); humanized mouse monoclonal h1F6 gamma heavy chain (221-218')-disulfide with humanized mouse monoclonal h1F6 kappa light chain dimer (227-227'':230-230'')- bisdisulfide

库存: 6,250 克
纯度: 99.3 %
CAS: 1160590-05-5

化合物标识与属性

CAS: 1160590-05-5
PubChem CID: 86278355
SMILES: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN3C(=O)CC(C3=O)SC[C@@H](C(=O)O)N
Canonical SMILES: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)CC(SC[C@H](N)C(=O)O)C1=O)C(C)C

名称与同义词

Cys-McMMAF
Denintuzumab mafodotin
Depatux-m
Vorsetuzumab mafodotin
Vorsetzumab Mafodotin
Depatuxizumab mafodotin
denintuzumab-mafodotin
SGN-CD19A
Cys-MC-MMAF
CYSTEINYL-MFFA
Denintuzumab mafodotin?
SGN-CD 19A
UNII-H5324S1M7H
Abbv-221
CYSTEINYL-MAFODOTIN
MAFODOTIN-CYSTEINYL
Vorsetzumab Mafodotin [USAN]
UNII-699619YVTQ
SGN 75
UNII-F3R7A4P04N
Denintuzumab mafodotin [USAN:INN]
B4S8ET206U
Depatuxizumab mafodotin [USAN]
F3R7A4P04N
H5324S1M7H
orb1982531
SGN-75
SCHEMBL29366663
EX-A9056E
ABT-414
1160590-05-5
699619YVTQ
BADC-01432
Vorsetuzumab mafodotin [USAN:INN]
DA-59044
DA-62611
MS-31894
HY-150233
MONOMETHYL AURISTATIN F CYSTEINYL-CONJUGATE
A1009824
1585973-65-4
1165741-01-4
1399672-02-6
Immunoglobulin G1-kappa auristatin F conjugate, anti-(homosapiens CD19 (b lymphocyte surface antigen B4, leu-12)), humanized monoclonal antibody
(2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[6-[3-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]hexanoyl-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl]-3-methoxy-2-methylpropanoyl]amino]-3-phenylpropanoic acid
Humanized mouse monoclonal immunoglobulin G1 anti-(human CD70 antigen) linked via thioether bonds to an average of 3 to 5 molecules of mafodotin: tetrakis(SCys- ((3RS)-1-(6-(((1S)-1-(((1S)-1-(((1S,2R)-4-((2S)-2-((1R,3R)-3-(((1S)-1-carboxy-2- phenylethyl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-2-methoxy-1-((1S)- 1-methylpropyl)-4-oxobutyl)methylcarbamoyl)-2-methylpropyl)carbamoyl)-2- methylpropyl)methylamino)-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl))immunoglobulin G1, anti-(human CD70 antigen (CD27 ligand, tumor necrosis factor ligand superfamily member 7)); humanized mouse monoclonal h1F6 gamma heavy chain (221-218')-disulfide with humanized mouse monoclonal h1F6 kappa light chain dimer (227-227'':230-230'')- bisdisulfide
Immunoglobulin G1, anti-(CD antigen CD70) (human-mouse monoclonal h1F6 heavy chain), disulfide with human-mouse monoclonal h1F6 light chain, dimer thioether with L-Phenylalanine, N-(6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl)-N-methyl-L- valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(alphaR,betaR,2S)-beta- methoxy-alpha-methyl-2-pyrrolidinepropanoyl-
Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human-Mus musculus monoclonal ABT-806 heavy chain), disulfide with human-Mus musculus monoclonal ABT-806 light chain, dimer, tetrakis(thioether) with N-(6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl)-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(alphaR,betaR,2S)-beta-methoxy-alpha-methyl-2-pyrrolidinepropanoyl-L-phenylalanine
L-Phenylalanine, N-[6-[3-[[(2R)-2-amino-2-carboxyethyl]thio]-2,5-dioxo-1-pyrrolidinyl]-1-oxohexyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(alphaR,betaR,2S)-beta-methoxy-alpha-methyl-2-pyrrolidinepropanoyl-
L-Valinamide, N-(6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl)-N-methyl-L-valyl-N-((1S,2R)-4-((2S)-2-((1S,2R)-3-(((1S)-1-carboxy-2-phenylethyl)amino)-1-methoxy-2-methyl-3-oxopropyl)-1-pyrrolidi nyl)-2-methoxy-1-((1S)-1-methylpropyl)-4-oxobutyl
N-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl)-N-methyl-L-valyl-N-((3R,4S,5S)-1-((2S)-2-((1S,2R)-3-(((1S)-1-carboxy-2-phenylethyl)amino)-1-methoxy-2-methyl-3-oxopropyl)-1-pyrrolidinyl)-3-methoxy-5-methyl-1-oxo-4-heptanyl)-N-methyl-L-valinamide