Chemical Compound

L-Phenylalanine, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(aR,ssR,2S)-ss-methoxy-a-methyl-2-pyrrolidinepropanoyl-; N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(aR,ssR,2S)-ss-methoxy-a-methyl-2-pyrrolidinepropanoyl-L-phenylalanine; Maleimidocaproyl monomethylauristatin F; Maleimidocaproyl-MMAF; McMMAF; SGD 1269; mc-MMAF; SGD-1269; GSK3206291A; GSK2857916

CAS Registry Number 863971-19-1
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L-Phenylalanine, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(aR,ssR,2S)-ss-methoxy-a-methyl-2-pyrrolidinepropanoyl-; N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(aR,ssR,2S)-ss-methoxy-a-methyl-2-pyrrolidinepropanoyl-L-phenylalanine; Maleimidocaproyl monomethylauristatin F; Maleimidocaproyl-MMAF; McMMAF; SGD 1269; mc-MMAF; SGD-1269; GSK3206291A; GSK2857916 结构式
Primary record

L-Phenylalanine, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(aR,ssR,2S)-ss-methoxy-a-methyl-2-pyrrolidinepropanoyl-; N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(aR,ssR,2S)-ss-methoxy-a-methyl-2-pyrrolidinepropanoyl-L-phenylalanine; Maleimidocaproyl monomethylauristatin F; Maleimidocaproyl-MMAF; McMMAF; SGD 1269; mc-MMAF; SGD-1269; GSK3206291A; GSK2857916

库存
1,438 克
纯度
99.6 %
CAS
863971-19-1

化合物标识与属性

CAS
863971-19-1
PubChem CID
56949327
SMILES
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN3C(=O)C=CC3=O
Canonical SMILES
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)C=CC1=O)C(C)C

名称与同义词

  • MC-MMAF
  • MAFODOTIN
  • McMMAF
  • Mafodotin [USAN]
  • 863971-19-1
  • Mafodotin (USAN)
  • MCMMA-F
  • McMMAF (GMP)
  • UNII-O19V2N6W9T
  • SGD-1269
  • RefChem:155132
  • Maleimidocaproyl monomethylauristatin F
  • O19V2N6W9T
  • MFCD25976741
  • orb1308052
  • CHEMBL2107813
  • SCHEMBL10220875
  • SGD-1269(MCMMAF)?
  • mc-MMAF, mcMMAF, SGD-1269
  • DTXCID20158012
  • DTXSID90235521
  • WLZ3756
  • BADC-00014
  • GLXC-21640
  • C49H76N6O11
  • EX-A3358
  • SGD 1269
  • HY-15578G
  • AKOS030526943
  • ZINC150341961
  • CS-5344
  • FM57972
  • AC-32507
  • AS-55899
  • BP-23981
  • HY-15578
  • SY034483
  • DB-095142
  • CS-0899301
  • NS00073453
  • J3.054.312B
  • C76806
  • D10339
  • A905593
  • Q27285195
  • (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylhexanamido)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid
  • 863971-19-1 (pyrrole-2,5-dione derivative; not the radical form)
  • ((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylhexanamido)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine
  • (2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoyl-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl]-3-methoxy-2-methylpropanoyl]amino]-3-phenylpropanoic acid
  • L-PHENYLALANINE, N-(6-(2,5-DIHYDRO-2,5-DIOXO-1H-PYRROL-1-YL)-1-OXOHEXYL)-N-METHYL-L-VALYL-L-VALYL-(3R,4S,5S)-3-METHOXY-5-METHYL-4-(METHYLAMINO)HEPTANOYL-(.ALPHA.R,.BETA.R,2S)-.BETA.-METHOXY-.ALPHA.-METHYL-2-PYRROLIDINEPROPANOYL-
  • (2S)-2-[(2R)-2-[(R)-[(2S)-1-[(3R,4S,5S)-4-[(2S)-2-[(2S)-2-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylhexanamido]-3-methylbutanamido]-N,3-dimethylbutanamido]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl](methoxy)methyl]propanamido]-3-phenylpropanoic
  • (2S)-2-[(2R)-2-[(R)-[(2S)-1-[(3R,4S,5S)-4-[(2S)-2-[(2S)-2-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylhexanamido]-3-methylbutanamido]-N,3-dimethylbutanamido]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl](methoxy)methyl]propanamido]-3-phenylpropanoic acid
  • (2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoyl-methyl-amino]-3-methyl-butanoyl]amino]-3-methyl-butanoyl]-methyl-amino]-3-methoxy-5-methyl-heptanoyl]pyrrolidin-2-yl]-3-methoxy-2-methyl-propanoyl]amino]-3-phenyl-propanoic acid
  • L-Phenylalanine, N-(6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl)-N-methyl-L- valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(alphaR,betaR,2S)-beta- methoxy-alpha-methyl-2-pyrrolidinepropanoyl-
  • L-PHENYLALANINE, N-(6-(2,5-DIHYDRO-2,5-DIOXO-1H-PYRROL-1-YL)-1-OXOHEXYL)-N-METHYL-L-VALYL-L-VALYL-(3R,4S,5S)-3-METHOXY-5-METHYL-4-(METHYLAMINO)HEPTANOYL-(ALPHAR,BETAR,2S)-BETA-METHOXY-ALPHA-METHYL-2-PYRROLIDINEPROPANOYL-
  • L-Phenylalanine, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(|_R,|_R,2S)-|_-methoxy-|_-methyl-2-pyrrolidinepropanoyl-
  • L-Phenylalanine, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(aR,ssR,2S)-ss-methoxy-a-methyl-2-pyrrolidinepropanoyl-; N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(aR,ssR,2S)-ss-methoxy-a-methyl-2-pyrrolidinepropanoyl-L-phenylalanine; Maleimidocaproyl monomethylauristatin F; Maleimidocaproyl-MMAF; McMMAF; SGD 1269; mc-MMAF; SGD-1269; GSK3206291A; GSK2857916
  • N-((2R,3R)-3-((2S)-1-((3R,4S,5S)-4-((N-(6-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1- YL)HEXANOYL)-N-METHYL-L-VALYL-L-VALYL(METHYLAMINO)-3-METHOXY-5- METHYLHEPTANOYL)PYRROLIDIN-2-YL)-3-METHOXY-2-METHYLPROPANOYL)-L-PHENYLALANINE
  • N-((2R,3R)-3-((2S)-1-((3R,4S,5S)-4-((N-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1- yl)hexanoyl)-N-methyl-L-valyl-L-valyl)methylamino)-3-methoxy-5- methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine
  • N-((2R,3R)-3-((2S)-1-((3R,4S,5S)-4-((N-(6-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)HEXANOYL)-N-METHYL-L-VALYL-L-VALYL(METHYLAMINO)-3-METHOXY-5-METHYLHEPTANOYL)PYRROLIDIN-2-YL)-3-METHOXY-2-METHYLPROPANOYL)-L-PHENYLALANINE
  • N-[(2R,3R)-2-Methyl-3-methoxy-3-[1-[(3R,4S,5S)-3-methoxy-4-[[N-[6-(2,5-dioxo-3-pyrroline-1-yl)hexanoyl]-N-methyl-L-Val-L-Val-](methyl)amino]-5-methylheptanoyl]pyrrolidine-2alpha-yl]propanoyl]-L-phenylalanine