Chemical Compound

Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-, compd. with 1,1'-sulfinylbis[methane] (1:1); GSK 1120212B; Trametinib dimethyl sulfoxide; GSK 1120212B

CAS Registry Number 1187431-43-1
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Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-, compd. with 1,1'-sulfinylbis[methane] (1:1); GSK 1120212B; Trametinib dimethyl sulfoxide; GSK 1120212B 结构式
Primary record

Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-, compd. with 1,1'-sulfinylbis[methane] (1:1); GSK 1120212B; Trametinib dimethyl sulfoxide; GSK 1120212B

库存
1,648 克
纯度
98.1 %
CAS
1187431-43-1

化合物标识与属性

CAS
1187431-43-1
PubChem CID
50992434
SMILES
CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5.CS(=O)C
Canonical SMILES
CC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1.CS(C)=O

名称与同义词

  • Trametinib DMSO
  • Trametinib DMSO solvate
  • TRAMETINIB DIMETHYL SULFOXIDE
  • Trametinib
  • 1187431-43-1
  • Mekinist
  • Mekinst
  • Trametinib (DMSO solvate)
  • UNII-BSB9VJ5TUT
  • Spexotras (TN)
  • BSB9VJ5TUT
  • Mekinist (TN)
  • GSK1120212B
  • Trametinib Impurity 28
  • RefChem:57976
  • Trametinib DMSO solvate?
  • CHEBI:75991
  • GSK-1120212B
  • GSK1120212 (DMSO solvate)
  • C28H29FIN5O5S
  • GSK1120212
  • DTXSID30152223
  • JTP 74057
  • Trametinib dimethyl sulfoxide [USAN]
  • orb1301426
  • SCHEMBL1516331
  • CHEMBL2105741
  • DTXCID0074714
  • SCHEMBL29786139
  • GSK 1120212B
  • MFCD21609250
  • OQUFJVRYDFIQBW-UHFFFAOYSA-N
  • C26H23FIN5O4.C2H6OS
  • GLXC-90089
  • HMS5086F12
  • GSK-1120212 (DMSO solvate
  • AMY30057
  • AOB87798
  • BCP06093
  • EX-A5800
  • KS-00000LF6
  • 4126AH
  • HY-10999A
  • s4484
  • AKOS027338667
  • ACN-041326
  • CS-0061
  • EBC-102134
  • FT65193
  • GSK-1120212
  • AC-30850
  • AK340973
  • AS-17069
  • DA-68297
  • Trametinib dimethyl sulfoxide (JAN/USAN)
  • TRAMETINIB DIMETHYL SULFOXIDE [MI]
  • TRAMETINIB DIMETHYL SULFOXIDE [JAN]
  • A3887
  • FT-0696678
  • TRAMETINIB DIMETHYL SULFOXIDE [WHO-DD]
  • D10176
  • W-5848
  • N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfinyl)methane (1:1)
  • ethyl 2-cyano-3-cyclohex-3-en-1-ylprop-2-enoate
  • TRAMETINIB DIMETHYL SULFOXIDE [ORANGE BOOK]
  • A1212063
  • N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide dimethyl sulfoxide complex
  • Q27145671
  • GSK-1120212 DMSO solvate;JTP-74057 DMSO solvate
  • N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide;methylsulfinylmethane
  • 118745-26-9
  • 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
  • 871700-17-3
  • Acetamide, N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-3,4,6,7-tetrahydro-6,8- dimethyl-2,4,7-trioxopyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)-, compd. with 1,1'- sulfinylbis(methane) (1:1)
  • ACETAMIDE, N-(3-(3-CYCLOPROPYL-5-((2-FLUORO-4-IODOPHENYL)AMINO)-3,4,6,7-TETRAHYDRO-6,8-DIMETHYL-2,4,7-TRIOXOPYRIDO(4,3-D)PYRIMIDIN-1(2H)-YL)PHENYL)-, COMPD. WITH 1,1'-SULFINYLBIS(METHANE) (1:1)
  • Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-, compd. with 1,1'-sulfinylbis[methane] (1:1); GSK 1120212B; Trametinib dimethyl sulfoxide; GSK 1120212B
  • Equimolecular combination of N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8- dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido(4,3-d)pyrimidin-1(2H)- yl)phenyl)acetamide with dimethyl-lambda(sup 4)-sulfanone
  • GSK-1120212 DMSO solvate;Trametinib;JTP-74057;GSK-1120212;GSK1120212;GSK 1120212;JTP 74057;JTP74057
  • N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)acetamide - (methylsulfinyl)methane (1:1)
  • N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)acetamide--(methylsulfinyl)methane (1/1)
  • N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfinyl)methane (1:
  • N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide(methylsulfinyl)methane
  • N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide--(methylsulfinyl)methane (1/1)
  • N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-1H,2H,3H,4H,6H,7H-pyrido[4,3-d]pyrimidin-1-yl}phenyl)acetamide; methanesulfinylmethane
  • N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide--(methylsulfinyl)methane (1/1)
  • N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodo-anilino)-6,8-dimethyl-2,4,7-trioxo-pyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide;methylsulfinylmethane
  • N-{3-[3-Cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl}acetamide--(methanesulfinyl)methane (1/1)