Chemical Compound

5-((1R,4R)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(difluoromethyl)-1-((1r,4R)-4-((4-((3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)prop-2-yn-1-yl)oxy)piperidin-1-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

CAS Registry Number 2432994-31-3
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5-((1R,4R)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(difluoromethyl)-1-((1r,4R)-4-((4-((3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)prop-2-yn-1-yl)oxy)piperidin-1-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 结构式
Primary record

5-((1R,4R)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(difluoromethyl)-1-((1r,4R)-4-((4-((3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)prop-2-yn-1-yl)oxy)piperidin-1-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

库存
3,324 克
纯度
99.2 %
CAS
2432994-31-3

化合物标识与属性

CAS
2432994-31-3
PubChem CID
146599824
SMILES
CN1C2=C(C=CC=C2N(C1=O)C3CCC(=O)NC3=O)C#CCOC4CCN(CC4)CC5CCC(CC5)N6C=C(C(=N6)C(F)F)NC(=O)C7=C8N=C(C=CN8N=C7)N9C[C@H]1C[C@@H]9CO1
Canonical SMILES
Cn1c(=O)n(C2CCC(=O)NC2=O)c2cccc(C#CCOC3CCN(CC4CCC(n5cc(NC(=O)c6cnn7ccc(N8C[C@H]9C[C@@H]8CO9)nc67)c(C(F)F)n5)CC4)CC3)c21

名称与同义词

  • Tipasertideg
  • PROTAC IRAK4 degrader-7
  • tipasertideg [INN]
  • KT-474
  • 2432994-31-3
  • KT474
  • 2SXR65P7E3
  • orb1982967
  • CHEMBL5569030
  • SCHEMBL21998241
  • SCHEMBL23807243
  • SCHEMBL25986139
  • SCHEMBL30332643
  • SCHEMBL30332644
  • GTPL12892
  • KYM-001
  • SAR444656
  • GLXC-26797
  • GLXC-27930
  • SAR-444656
  • EX-A8217
  • KT-I-417
  • MFCD35054646
  • AT41570
  • KT-474?
  • Compound A [WO2022174269A1]
  • BK184142
  • DA-77150
  • SY375894
  • HY-145483
  • CS-0374973
  • N-[3-(Difluoromethyl)-1-[trans-4-[[4-[[3-[1-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-4-yl]-2-propyn-1-yl]oxy]-1-piperidinyl]methyl]cyclohexyl]-1H-pyrazol-4-yl]-5-(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylpyrazolo[1,5-a]pyrimidine-3-carboxamide
  • N-[3-(Difluoromethyl)-1-[4-[[4-[3-[1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxobenzimidazol-4-yl]prop-2-ynoxy]piperidin-1-yl]methyl]cyclohexyl]pyrazol-4-yl]-5-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
  • 5-((1R,4R)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(difluoromethyl)-1-((1r,4R)-4-((4-((3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)prop-2-yn-1-yl)oxy)piperidin-1-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
  • 5-[(1R,4R)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl]-N-[3-(difluoromethyl)-1-[trans-4-[[4-[[3-[1-(2,6-dioxo-3-piperidyl)-3-methyl-2-oxo-2,3-dihydro-4-benzimidazolyl]-2-propyn-1-yl]oxy]-1-piperidyl]methyl]cyclohexyl]-4-pyrazolyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
  • PYRAZOLO(1,5-A)PYRIMIDINE-3-CARBOXAMIDE, N-(3-(DIFLUOROMETHYL)-1-(TRANS-4-((4-((3-(1-(2,6-DIOXO-3-PIPERIDINYL)-2,3-DIHYDRO-3-METHYL-2-OXO-1H-BENZIMIDAZOL-4-YL)-2-PROPYN-1-YL)OXY)-1-PIPERIDINYL)METHYL)CYCLOHEXYL)-1H-PYRAZOL-4-YL)-5-(1R,4R)-2-OXA-5-AZABICYCLO(2.2.1)HEPT-5-YL-