Chemical Compound

6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxy-ethanesulfonic acid (1:1)

CAS Registry Number 439081-18-2
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6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxy-ethanesulfonic acid (1:1) 结构式
Primary record

6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxy-ethanesulfonic acid (1:1)

库存
5,737 克
纯度
98.4 %
CAS
439081-18-2

化合物标识与属性

CAS
439081-18-2
PubChem CID
10184653
SMILES
CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
Canonical SMILES
CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1

名称与同义词

  • Afatinib
  • Tovok
  • Tomtovok
  • BIBW2992
  • 439081-18-2
  • 850140-72-6
  • afatinibum
  • BIBW 2992
  • Gilotrif
  • (E/Z)-Afatinib
  • Afatinib maleate
  • Afatinib free base
  • Afatinib, Free Base
  • BIBW-2992
  • Afatinib [USAN]
  • Afatinib (BIBW2992)
  • Afatinib E-Isomer
  • (S)-Afatinib
  • Tovok,BIBW2992
  • BIBW2992 (Tovok)
  • C24H25ClFN5O3
  • Tovok (TN)
  • Afatinib [USAN:INN]
  • BIBW2992 Afatinib
  • BIBW2992,Afatinib
  • RefChem:56995
  • Afatinib (USAN/INN)
  • AFATINIB [INN]
  • AFATINIB [MI]
  • AFATINIB DIMALEATE
  • Tovok, BIBW2992
  • AFATINIB [VANDF]
  • EGFR inhibitor 2nd gens
  • GlyTouCan:G02851FW
  • AFATINIB [MART.]
  • BIBW2992 - Afatinib
  • MFCD12407405
  • AFATINIB [WHO-DD]
  • D05UFG
  • UNII-41UD74L59M
  • 41UD74L59M
  • Tovok|||BIBW 2992
  • CHEMBL1173655
  • (E/Z)-Afatinib (Standard)
  • Afatinib - Bio-X trade mark
  • cc-109
  • CHEBI:61390
  • MLS006010000
  • orb322739
  • NSC-750691
  • SCHEMBL232772
  • DTXSID20893451
  • EX-A065A
  • GTPL5667
  • orb1306404
  • SCHEMBL29388685
  • SCHEMBL29395096
  • BIBW-2929
  • CHEBI:94698
  • 850140-72-6 (free base)
  • EX-A065
  • L01XE13
  • QCR-169
  • NSC750691
  • ULXXDDBFHOBEHA-CWDCEQMOSA-N
  • (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
  • BCPP000338
  • BIBW 29 92
  • DTXCID301323466
  • GLXC-21899
  • GLXC-90096
  • HY-10261BR
  • Afatinib, 99% - 25MG 25mg
  • AMX10177
  • AOB87785
  • BCP01779
  • G02851FW
  • ZINC3976838
  • BIBW2992/Tovok,BIBW-2992
  • 3123AC
  • ABP000859
  • AN-537
  • BDBM50322823
  • EBC-12394
  • HY-10261B
  • MFCD31630115
  • MSK162749
  • NSC799327
  • Afatinib(cis-trans isomerismtautomers)
  • AKOS015850681
  • AKOS015904219
  • AKOS025149636
  • ACN-036294
  • BCP9000407
  • CCG-264776
  • DB08916
  • EX-8656
  • FC17230
  • NSC-799327
  • RL05240
  • SDCCGSBI-0654325.P001
  • CID10184653
  • NCGC00185000-01
  • NCGC00185000-22
  • NCGC00185000-23
  • S1011
  • AC-26079
  • AC-27018
  • AJ-47553
  • AM808098
  • AS-80916
  • BA164141
  • BP-43626
  • CID 10184653
  • DS-14172
  • SC-66830
  • SC-87772
  • SMR004701084
  • SY028094
  • SY047316
  • AB0033685
  • N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-Butenamide
  • PD0332991
  • TC-162525
  • TC-163608
  • A2870
  • A8247
  • CS-0020030
  • FT-0651456
  • FT-0661434
  • NS00077621
  • ST24036355
  • SW219248-1
  • X7366
  • (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
  • J2.685.397D
  • J3.363.130H
  • A10141
  • A15572
  • D09724
  • Q-3651
  • AB01565886_02
  • EN300-6487482
  • 081B182
  • A850102
  • EN300-19625328
  • F050665
  • SR-01000941576
  • (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-oxolan-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
  • (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
  • (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
  • Q4688818
  • SR-01000941576-1
  • 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino
  • BRD-K66175015-001-01-7
  • BRD-K66175015-001-09-0
  • BRD-K66175015-001-13-2
  • BRD-K66175015-332-01-6
  • I14-17009
  • (2E)-N-(4-(3-chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide
  • Z2568727518
  • B0084-092426
  • B0084-258486
  • (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(dimethylamino)but-2-enamide
  • (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide.
  • (S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
  • 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-, (2E)-
  • N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-oxolan-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
  • (2e)-n-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3s)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-2-butenamide
  • (2E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((3S)-oxolan-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
  • (2E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((3S)-tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
  • (2E)-N-[4-(3-Chloro-4-fluoroanilino)-7-[[(3S)-oxolane-3-yl]oxy]quinazoline-6-yl]-4-(dimethylamino)-2-buteneamide
  • (2E)-N-[4-(3-Chloro-4-fluoroanilino)-7-{[(3S)-oxolan-3-yl]oxy}quinazolin-6-yl]-4-(dimethylamino)but-2-enamide
  • (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
  • (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; BIBW 2992;
  • (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydrofuran-3-yl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-buteneamide
  • (E)-4-dimethylamino-but-2-enoic acid-(4-(3-chloro-4-fluoro-phenylamino)-7-((S)-tetrahydrofuran-3-yloxy)-quinazolin-6-yl)-amide
  • (E)-4-dimethylamino-but-2-enoic acid-(4-(3-chloro-4-fluoro-phenylamino)-7-((S)-tetrahydrofuran-3-yloxy)-quinazolin-6yl)-amide
  • (E)-4-Dimethylamino-but-2-enoic acid-[4-(3-chloro-4-fluoro-phenylamino)-7-((S)-tetrahydrofuran-3-yloxy)-quinazolin-6-yl]-amide
  • (E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(S)-tetrahydrofuran-3-yl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
  • (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
  • (S)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[(3-tetrahydrofuranyl)oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
  • 0WM
  • 1254955-21-9
  • 2-butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)- 6-quinazolinyl)-4-(dimethylamino)-, (2E)-
  • 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-
  • 2-BUTENAMIDE, N-[4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-7-[[(3S)-TETRAHYDRO-3-FURANYL]OXY]-6-QUINAZOLINYL]-4-(DIMETHYLAMINO)-
  • 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
  • 2-Butenamide,N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-,(2E)-
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxy-ethanesulfonic acid (1:1)
  • 810-720-4
  • N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3''S'')-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide
  • N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide
  • N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(S)-tetrahydrofuran-3-yl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-buteneamide